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Safety profile of GLP-1-based multi-agonists: common adverse events, frequency estimates, and clinical considerations Abbreviations GIP glucose-dependent insulinotropic polypeptide HFpEF heart failure with preserved ejection fraction MACE major adverse cardiovascular events MASH metabolic dysfunction-associated steatohepatitis MASLD metabolic dysfunction-associated steatotic liver disease MRI-PDFF magnetic resonance imaging proton density fat fraction MTC medullary thyroid carcinoma NUSH nutrient-stimulated hormone QALY Quality-Adjusted Life Year QSP quantitative systems-pharmacology STEP Semaglutide Treatment Effect in People with Obesity REFERENCES 1